On July 6, 1933, the first MLB All Star Game was played at Comiskey Park in Chicago. Arch Ward, then Sports Editor for the Chicago Tribune, came up with the idea for the game which coincided with Chicago's World's Fair Celebration. (In Ward's honor, the game's MVP award was originally called the Arch Ward Trophy before being changed to the Commissioner's Trophy in 1970 and then to the Ted Williams MVP Award in 2002.)
The American League team was managed by Connie Mack, manager of the Philadelphia Athletics. John McGraw, former manager of the NY Giants, was chosen as the manager of the NL squad, even though he retired in 1932. The game was won by the American League by a score of 4 - 2. The Yankees pretty much dominated with Babe Ruth hitting a 2 run home run in the third inning and pitcher Lefty Gomez getting the win.

Babe Ruth crosses the plate after hitting the first ever All Star game HR.
American League Roster
Earl Averill - Cleveland Indians
Ben Chapman - New York Yankees
Jon Cronin - Washington Senators
General Crowder - Washington Senators
Bill Dickey - New York Yankees
Jimmy Dykes - Chicago White Sox
Rick Ferrell - Boston Red Sox
Wes Ferrell - Cleveland Indians
Jimmie Foxx - Philadelphia Athletics
Lou Gehrig - New York Yankees
Charlie Gehringer - Detroit Tigers
Lefty Gomes - New York Yankees
Lefty Grove - Philadelphia Athletics
Oral Hildebrand - Cleveland Indians
Tony Lazzeri - New York Yankees
Babe Ruth - New York Yankees
Al Simmons - Chicago White Sox
Sam West - St. Louis Browns
National League Roster
Dick Bartell - Philadelphia Phillies
Wally Berger - Boston Braves
Tony Cuccinello - Brooklyn Dodgers
Woody English - Chicago Cubs
Frankie Frisch - St. Louis Cardinals
Chick Hafey - Cincinnati Reds
Bill Hallahan - St. Louis Cardinals
Gabby Hartnett - Chicago Cubs
Carl Hubbell - New York Giants
Chuck Klein - Philadelphia Phillies
Pepper Martin - St. Louis Cardinals
Lefty O'Doul - New York Giants
Hal Schumacher - New York Giants
Bill Terry - New York Giants
Pie Traynor - Pittsburgh Pirates
Paul Waner - Pittsburgh Pirates
Lou Warneke - Chicago Cubs
Jimmie Wilson - St. Louis Cardinals